In his response to this TMZ reporter's question, our man N.D.T. said smoking weed in space is "not in the interest of your health."
He said there's enough in space that can kill you already so doing anything to "alter your perception of reality" further is not a good idea.
According to Neil, if you're so bold and decide to be even higher than the clouds, you should just lock yourself in your cabin and stay there for awhile. Source: Motherboard